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Genetic variation of macronutrient tolerance in Drosophila melanogaster.
Havula, E; Ghazanfar, S; Lamichane, N; Francis, D; Hasygar, K; Liu, Y; Alton, L A; Johnstone, J; Needham, E J; Pulpitel, T; Clark, T; Niranjan, H N; Shang, V; Tong, V; Jiwnani, N; Audia, G; Alves, A N; Sylow, L; Mirth, C; Neely, G G; Yang, J; Hietakangas, V; Simpson, S J; Senior, A M.
Afiliación
  • Havula E; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia. essi.havula@helsinki.fi.
  • Ghazanfar S; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia. essi.havula@helsinki.fi.
  • Lamichane N; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. essi.havula@helsinki.fi.
  • Francis D; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Hasygar K; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Liu Y; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
  • Alton LA; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
  • Johnstone J; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Needham EJ; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
  • Pulpitel T; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
  • Clark T; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
  • Niranjan HN; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
  • Shang V; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia.
  • Tong V; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia.
  • Jiwnani N; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Audia G; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Alves AN; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Sylow L; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Mirth C; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Neely GG; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Yang J; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Hietakangas V; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Simpson SJ; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
  • Senior AM; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia.
Nat Commun ; 13(1): 1637, 2022 03 28.
Article en En | MEDLINE | ID: mdl-35347148
ABSTRACT
Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Drosophila / Drosophila melanogaster Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Drosophila / Drosophila melanogaster Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Australia