Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells.
Bull Exp Biol Med
; 172(5): 632-636, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-35352256
ABSTRACT
The regenerative properties of p-tyrosol were investigated in a model of testicular insufficiency caused by a toxic effect on spermatogonial stem cells (single administration of paclitaxel in the maximum tolerable dose). Against the background of p-tyrosol administration, we observed an increase in the number of normal spermatogonia and Sertoli cells, stimulation of spermatogenesis, and renewal of the spermatogenic tissue. The treatment with p-tyrosol also led to a decrease in DNA damage in cells of the testicular tissue. These changes were accompanied by a decrease in the level of free radicals, an increase in antioxidant protection, and normalization of the redox potential.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espermatogonias
/
Testículo
Límite:
Humans
/
Male
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Rusia