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USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.
Xiong, Wenjun; Gao, Xueliang; Zhang, Tiantian; Jiang, Baishan; Hu, Ming-Ming; Bu, Xia; Gao, Yang; Zhang, Lin-Zhou; Xiao, Bo-Lin; He, Chuan; Sun, Yishuang; Li, Haiou; Shi, Jie; Xiao, Xiangling; Xiang, Bolin; Xie, Conghua; Chen, Gang; Zhang, Haojian; Wei, Wenyi; Freeman, Gordon J; Shu, Hong-Bing; Wang, Haizhen; Zhang, Jinfang.
Afiliación
  • Xiong W; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
  • Gao X; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Zhang T; Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
  • Jiang B; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Hu MM; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Bu X; Center for Protein Degradation, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Gao Y; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Zhang LZ; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
  • Xiao BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • He C; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China.
  • Sun Y; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.
  • Li H; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Shi J; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430071, Wuhan, China.
  • Xiao X; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Xiang B; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430071, Wuhan, China.
  • Xie C; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
  • Chen G; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Zhang H; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
  • Wei W; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Freeman GJ; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
  • Shu HB; Department of Dermatology, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
  • Wang H; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
  • Zhang J; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China.
Nat Commun ; 13(1): 1700, 2022 03 31.
Article en En | MEDLINE | ID: mdl-35361799
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endopeptidasas / Ubiquitina Tiolesterasa / Complejos de Clasificación Endosomal Requeridos para el Transporte / Microambiente Tumoral / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endopeptidasas / Ubiquitina Tiolesterasa / Complejos de Clasificación Endosomal Requeridos para el Transporte / Microambiente Tumoral / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido