Multiple roles for basement membrane proteins in cancer progression and EMT.
Eur J Cell Biol
; 101(2): 151220, 2022 Apr.
Article
en En
| MEDLINE
| ID: mdl-35366585
ABSTRACT
Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics. DATA AVAILABILITY:
Not applicable.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transición Epitelial-Mesenquimal
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Eur J Cell Biol
Año:
2022
Tipo del documento:
Article
País de afiliación:
India