Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.

Abskharon, Romany; Sawaya, Michael R; Boyer, David R; Cao, Qin; Nguyen, Binh A; Cascio, Duilio; Eisenberg, David S

Abskharon, Romany; Sawaya, Michael R; Boyer, David R; Cao, Qin; Nguyen, Binh A; Cascio, Duilio; Eisenberg, David S.

Afiliación

Abskharon R; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1570.
Sawaya MR; Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1570.
Boyer DR; US Department of Energy, Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095-1570.
Cao Q; Molecular Biology Institute, University of California, Los Angeles, CA 90095-1570.
Nguyen BA; HHMI, University of California, Los Angeles, CA 90095-1570.
Cascio D; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1570.
Eisenberg DS; Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1570.

Proc Natl Acad Sci U S A ; 119(15): e2119952119, 2022 04 12.

Article en En | MEDLINE | ID: mdl-35377792

Asunto(s)

Amiloide; ARN; Proteínas tau; Amiloide/química; Microscopía por Crioelectrón; Humanos; ARN/química; Proteínas tau/química

Palabras clave

Alzheimer's; RNA; amyloid; cryo-EM; tau

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Proteínas tau / Amiloide Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos

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