Neuroinflammation, Stem Cells, and Stroke.
Stroke
; 53(5): 1460-1472, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-35380050
ABSTRACT
Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United States and around the world. Accordingly, finding safe and effective novel treatments with a wider therapeutic window stands as an urgent need in stroke. The progressive inflammation that occurs centrally and peripherally after stroke serves as a unique therapeutic target to retard and even halt the secondary cell death. Stem cell therapy represents a potent approach that can diminish inflammation in both the stroke brain and periphery (eg, spleen), advancing a paradigm shift from a traditionally brain-focused therapy to treating stroke as a neurological disorder with a significant peripheral pathology. The purpose of this review article is to highlight the inflammation-mediated secondary cell death that plagues both brain and spleen in stroke and to evaluate the therapeutic potential of stem cell therapy in dampening these inflammatory responses.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Accidente Cerebrovascular
/
Enfermedades Neuroinflamatorias
Tipo de estudio:
Etiology_studies
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Stroke
Año:
2022
Tipo del documento:
Article