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Expanding PAM recognition and enhancing base editing activity of Cas9 variants with non-PI domain mutations derived from xCas9.
Xie, Lifang; Hu, Yun; Li, Li; Jiang, Lurong; Jiao, Yaoge; Wang, Yanhong; Zhou, Lifang; Tao, Rui; Qu, Junyan; Chen, Qiang; Yao, Shaohua.
Afiliación
  • Xie L; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Hu Y; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
  • Li L; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Jiang L; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Jiao Y; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Wang Y; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Zhou L; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Tao R; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Qu J; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Chen Q; Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
  • Yao S; Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
FEBS J ; 289(19): 5899-5913, 2022 10.
Article en En | MEDLINE | ID: mdl-35411720
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas CRISPR-Cas / Proteína 9 Asociada a CRISPR Idioma: En Revista: FEBS J Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas CRISPR-Cas / Proteína 9 Asociada a CRISPR Idioma: En Revista: FEBS J Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido