Disruption of peroxisome proliferator-activated receptor &#945; in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway.

Zhang, Zhenzhen; Yao, Tiantian; Zhao, Nan; Liu, Hui; Cheng, Hao; Gonzalez, Frank J; Wang, Hua; Wang, Guiqiang; Qu, Aijuan; Wang, Yan

Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway.

Zhang, Zhenzhen; Yao, Tiantian; Zhao, Nan; Liu, Hui; Cheng, Hao; Gonzalez, Frank J; Wang, Hua; Wang, Guiqiang; Qu, Aijuan; Wang, Yan.

Afiliación

Zhang Z; Department of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Yao T; Department of Hepatic Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China.
Zhao N; Department of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Liu H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China.
Cheng H; Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Gonzalez FJ; Department of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Wang H; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, 20892, USA.
Wang G; Department of Pharmacy, Anhui Medical University; Department of Oncology, the First Affiliated Hospital, Institute for Liver Diseases of Anhui Medical University, Hefei, 230032, China.
Qu A; Department of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Wang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China.

Int J Biol Sci ; 18(6): 2317-2328, 2022.

Article en En | MEDLINE | ID: mdl-35414769

Asunto(s)

Enfermedad Hepática Crónica Inducida por Sustancias y Drogas; Enfermedad Hepática Inducida por Sustancias y Drogas; Acetaminofén/toxicidad; Animales; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/metabolismo; Sistema Enzimático del Citocromo P-450/metabolismo; Hepatocitos/metabolismo; Interleucina-6/metabolismo; Hígado/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; PPAR alfa/genética; PPAR alfa/metabolismo; Factor de Transcripción STAT3/genética; Factor de Transcripción STAT3/metabolismo

Palabras clave

Acetaminophen (APAP); Hepatotoxicity; IL-6/STAT3; Liver injury; Liver repair; Oxidative stress; Peroxisome proliferator-activated receptor α (PPARα)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Hepática Inducida por Sustancias y Drogas / Enfermedad Hepática Crónica Inducida por Sustancias y Drogas Límite: Animals Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia

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