Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with ß-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations.
ACS Omega
; 7(13): 11208-11216, 2022 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-35415366
ABSTRACT
Our present study intended to investigate the encapsulation of DL-AGT within the lipophilic cavity of a ß-CD molecule. The consequential inclusion system was characterized by UV-visible spectroscopy and 1H NMR, PXRD, SEM, and FT-IR studies. Molecular docking was performed for the inclusion complex to discover the most proper orientation, and it was seen that the drug DL-AGT fits into the cavity of ß-CD in a 11 ratio, which was also confirmed from the Job plot. Furthermore, a comparison was done on the basis of cell viability between the drug and its inclusion complex.
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01-internacional
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MEDLINE
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En
Revista:
ACS Omega
Año:
2022
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Article