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Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".
Alvarez-Buylla, Arturo; Cebrian-Silla, Arantxa; Sorrells, Shawn F; Nascimento, Marcos Assis; Paredes, Mercedes F; Garcia-Verdugo, Jose Manuel; Yang, Zhengang; Huang, Eric J.
Afiliación
  • Alvarez-Buylla A; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
  • Cebrian-Silla A; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
  • Sorrells SF; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
  • Nascimento MA; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
  • Paredes MF; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Garcia-Verdugo JM; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
  • Yang Z; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
  • Huang EJ; Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
Science ; 376(6590): eabn8861, 2022 04 15.
Article en En | MEDLINE | ID: mdl-35420933
Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin+ astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Neurogénesis / Hipocampo Límite: Adult / Humans Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Neurogénesis / Hipocampo Límite: Adult / Humans Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos