Metamorphosis of neutrophil transcriptional programme during Leishmania infection.
Parasite Immunol
; 44(6): e12922, 2022 06.
Article
en En
| MEDLINE
| ID: mdl-35437801
ABSTRACT
The role of neutrophils in the course of Leishmania infection remains controversial, displaying tremendous variability depending on the species of parasite, stage of infection, host genetic background, and methodological discrepancies among studies. Although neutrophils have long been categorized as short-lived cells with limited capacity to express proteins de novo, recent advances have revealed significant plasticity in neutrophil transcriptional programmes and intrapopulation heterogeneity, which can be regulated by both intrinsic and extrinsic factors that together determine the profile of neutrophil effector response. In this review, we focus on the current understanding of neutrophil transcriptional plasticity, neutrotime, evidence of Leishmania-mediated alterations in neutrophil transcriptome leading to the rise of subpopulations, and finally, functional implications of those findings to the course of Leishmania infection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leishmaniasis
/
Leishmania
Límite:
Humans
Idioma:
En
Revista:
Parasite Immunol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil