AlphaFold illuminates half of the dark human proteins.

Binder, Jessica L; Berendzen, Joel; Stevens, Amy O; He, Yi; Wang, Jian; Dokholyan, Nikolay V; Oprea, Tudor I

Binder, Jessica L; Berendzen, Joel; Stevens, Amy O; He, Yi; Wang, Jian; Dokholyan, Nikolay V; Oprea, Tudor I.

Afiliación

Binder JL; Translational Informatics Division, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: https://twitter.com/@jessicamaine.
Berendzen J; Translational Informatics Division, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Stevens AO; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA.
He Y; Translational Informatics Division, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Wang J; Department of Pharmacology, Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA 17033, USA.
Dokholyan NV; Department of Pharmacology, Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA 17033, USA; Department of Chemistry and Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, United States.
Oprea TI; Translational Informatics Division, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA; UNM Comprehensive Cancer Center, Albuquerque, NM, USA; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Goth

Curr Opin Struct Biol ; 74: 102372, 2022 06.

Article en En | MEDLINE | ID: mdl-35439658

Asunto(s)

Furilfuramida; Proteínas; Descubrimiento de Drogas; Humanos; Pliegue de Proteína; Proteínas/química

Palabras clave

Artificial intelligence; Drug discovery; Model evaluation; Protein folding; Understudied proteins; Virtual screening

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Furilfuramida Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Curr Opin Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article

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