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Engineered nasal dry powder for the encapsulation of bioactive compounds.
Baldelli, Alberto; Boraey, Mohammed A; Oguzlu, Hale; Cidem, Aylin; Rodriguez, Athenea Pascual; Ong, Hui Xin; Jiang, Feng; Bacca, Mattia; Thamboo, Andrew; Traini, Daniela; Pratap-Singh, Anubhav.
Afiliación
  • Baldelli A; Faculty of Land and Food Systems, The University of British Columbia, BC, Canada. Electronic address: baldelli@mail.ubc.ca.
  • Boraey MA; Mechanical Power Engineering Department, Zagazig University, Zagazig 44519, Egypt; Smart Engineering Systems Research Center (SESC), Nile University, Giza 12588, Egypt. Electronic address: boraey@ualberta.ca.
  • Oguzlu H; Department of Forestry, University of British Columbia, BC, Canada.
  • Cidem A; Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia.
  • Rodriguez AP; Department of Surgery, The University of British Columbia, BC, Canada.
  • Ong HX; Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia.
  • Jiang F; Department of Forestry, University of British Columbia, BC, Canada.
  • Bacca M; Department of Mechanical Engineering, University of British Columbia, BC, Canada.
  • Thamboo A; Department of Surgery, The University of British Columbia, BC, Canada.
  • Traini D; Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia.
  • Pratap-Singh A; Faculty of Land and Food Systems, The University of British Columbia, BC, Canada.
Drug Discov Today ; 27(8): 2300-2308, 2022 08.
Article en En | MEDLINE | ID: mdl-35452791
In this review, we present the potential of nasal dry powders to deliver stable bioactive compounds and their manufacture using spray-drying (SD) techniques to achieve encapsulation. We also review currently approved and experimental excipients used for powder manufacturing for specific target drugs. Polymers, sugars, and amino acids are recommended for specific actions, such as mucoadhesive interactions, to increase residence time on the nasal mucosa; for example, high-molecular weight polymers, such as hydroxypropyl methylcellulose, or mannitol, which protect the bioactive compounds, increase their stability, and enhance drug absorption in the nasal mucosa; and leucine, which promotes particle formation and improves aerosol performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Inhaladores de Polvo Seco Idioma: En Revista: Drug Discov Today Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Inhaladores de Polvo Seco Idioma: En Revista: Drug Discov Today Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido