Structure and antioxidant activity of six mushroom-derived heterogalactans.
Int J Biol Macromol
; 209(Pt A): 1439-1449, 2022 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-35461867
ABSTRACT
Heterogalactans with weight-average molecular weights ~20 kDa were purified from several species of mushroom Hypsizygus marmoreus, Pleurotus ostreatus, Pholiota nameko, Agrocybe cylindracea, Hygrophorus lucorum and Hericium erinaceus, and structurally characterized and assessed for antioxidant activity in vitro. Methylation analysis, combined with NMR spectral analysis, indicates that these glycans have a common backbone composed of (1 â 6)-linked-α-D-galactopyranosyl residues that are substituted at O-2. The (1 â 6)-α-D-galactans, branched primarily with ß-D-mannopyranosyl (Manp) or α-L-fucopyranosyl (Fucp) residues, have been assigned to mannogalactans or fucogalactans, respectively, as well as to ß-D-Manp and α-L-Fucp residues attached in tandem to the main chain as fucomannogalactans. In addition, 3-O-methylated-α-D-galactopyranosyl (3-O-Me-Galp) residues within the mannogalactan chains, exhibit strong reducing power and radical scavenging activity suggesting that this sugar moiety functions as an antioxidant. Our results provide important structural information on mushroom heterogalactans and prompt further investigations into their structure-activity relationships.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pleurotus
/
Agaricales
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2022
Tipo del documento:
Article