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How fluorescent labels affect the kinetics of the toehold-mediated DNA strand displacement reaction.
Li, Chengxu; Li, Zhigang; Han, Wenjie; Yin, Xue; Liu, Xiaoyu; Xiao, Shiyan; Liang, Haojun.
Afiliación
  • Li C; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
  • Li Z; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
  • Han W; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
  • Yin X; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
  • Liu X; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
  • Xiao S; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
  • Liang H; Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. xiaosy@ustc.edu.cn.
Chem Commun (Camb) ; 58(39): 5849-5852, 2022 May 12.
Article en En | MEDLINE | ID: mdl-35467686
End modification of the toehold domain or near to it using fluorophore dyes or quenchers can significantly modulate the kinetics of the toehold-mediated strand displacement reaction (TMSDR) by almost two orders of magnitude. The labels at the end of the signal strand impede the TMSDR, while those at the end of the toehold domain of the substrate strand accelerate the TMSDR kinetics.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Colorantes Fluorescentes Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Colorantes Fluorescentes Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido