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TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model.
Shao, Eric; Chang, Che-Wei; Li, Zhiyong; Yu, Xinxing; Ho, Kaitlyn; Zhang, Michelle; Wang, Xin; Simms, Jeffrey; Lo, Iris; Speckart, Jessica; Holtzman, Julia; Yu, Gui-Qiu; Roberson, Erik D; Mucke, Lennart.
Afiliación
  • Shao E; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Chang CW; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Li Z; Alzheimer's Disease Center, Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Yu X; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Ho K; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Zhang M; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Wang X; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Simms J; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Lo I; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Speckart J; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Holtzman J; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Yu GQ; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Roberson ED; Alzheimer's Disease Center, Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Mucke L; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
Sci Transl Med ; 14(642): eabm5527, 2022 04 27.
Article en En | MEDLINE | ID: mdl-35476595
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Proteínas tau / Epilepsias Mioclónicas / Epilepsia / Muerte Súbita e Inesperada en la Epilepsia Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Infant Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Proteínas tau / Epilepsias Mioclónicas / Epilepsia / Muerte Súbita e Inesperada en la Epilepsia Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Infant Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos