Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents.
RSC Adv
; 10(50): 30223-30237, 2020 Aug 10.
Article
en En
| MEDLINE
| ID: mdl-35518245
ABSTRACT
Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cytotoxicity against glioblastomas (GBM6) and triple negative breast cancer (MDA MB 231). Interestingly, compounds 4d and 4n showed significant activity against HCMV (IC50 â¼ 10 µM), while 4l and 5f revealed the highest cytotoxicity with IC50 = 36 to 80 µM. The synthetic efficacy and biological relevance offer an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.
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01-internacional
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MEDLINE
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En
Revista:
RSC Adv
Año:
2020
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Article