Metal-free oxidative trifluoromethylation of indoles with CF<sub>3</sub>SO<sub>2</sub>Na on the C2 position.

Xie, Jiao-Jiao; Wang, Zhi-Qing; Jiang, Guo-Fang

Metal-free oxidative trifluoromethylation of indoles with CF₃SO₂Na on the C2 position.

Xie, Jiao-Jiao; Wang, Zhi-Qing; Jiang, Guo-Fang.

Afiliación

Xie JJ; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 P. R. China gfjiang@hnu.edu.cn.
Wang ZQ; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 P. R. China gfjiang@hnu.edu.cn.
Jiang GF; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 P. R. China gfjiang@hnu.edu.cn.

RSC Adv ; 9(60): 35098-35101, 2019 Oct 28.

Article en En | MEDLINE | ID: mdl-35530675

ABSTRACT

ABSTRACT

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2019 Tipo del documento: Article