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Cytopathogenic effect of Salmonella typhi GIFU 10007 on M cells of murine ileal Peyer's patches in ligated ileal loops: an ultrastructural study.
Microbiol Immunol ; 30(12): 1225-37, 1986.
Article en En | MEDLINE | ID: mdl-3553868
ABSTRACT
An electron microscopic study revealed that, within 30 min after inoculation into the ligated ileal loop of anesthetized mice, cells of Salmonella typhi GIFU 10007 adhered to the M cell surface of Peyer's patch lymphoid follicle epithelium, and induced almost complete destruction of M cells. The M cell cytoplasms were pinched off and extruded from the epithelial lining into the luminal space together with the lymphoid cells primarily enfolded into the corresponding M cells. When two or more M cells were destroyed, a large defect in the epithelial lining was apparent, and a number of bacteria appeared near the basal lamina of the epithelial lining. These findings suggest, as far as anesthetized murine ileal loops and strain 10007 are concerned, that ileal M cells are the target cell at an early stage of S. typhi infection and the infection may further progress to deeper tissues and to the general circulation.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglios Linfáticos Agregados / Salmonella typhi Límite: Animals Idioma: En Revista: Microbiol Immunol Año: 1986 Tipo del documento: Article
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglios Linfáticos Agregados / Salmonella typhi Límite: Animals Idioma: En Revista: Microbiol Immunol Año: 1986 Tipo del documento: Article