Molecular insights into binding dynamics of tandem RNA recognition motifs (tRRMs) of human antigen R (HuR) with mRNA and the effect of point mutations in impaired HuR-mRNA recognition.

Agarwal, Ankita; Alagar, Suresh; Kant, Shri; Bahadur, Ranjit Prasad

Agarwal, Ankita; Alagar, Suresh; Kant, Shri; Bahadur, Ranjit Prasad.

Afiliación

Agarwal A; School of Bio Science, Indian Institute of Technology Kharagpur, Kharagpur, India.
Alagar S; Computational Structural Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.
Kant S; Computational Structural Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.
Bahadur RP; Computational Structural Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.

J Biomol Struct Dyn ; 41(11): 4830-4846, 2023 07.

Article en En | MEDLINE | ID: mdl-35538713

Asunto(s)

Mutación Puntual; Motivo de Reconocimiento de ARN; Humanos; Proteínas ELAV/química; Proteínas ELAV/genética; Proteínas ELAV/metabolismo; ARN/química; ARN Mensajero/genética

Palabras clave

HuR-RNA interactions; RNA recognition motifs; binding free energy; conformational rearrangement; molecular dynamics simulation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mutación Puntual / Motivo de Reconocimiento de ARN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biomol Struct Dyn Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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