Total synthesis of squafosacin F: stereodivergent approach to mono-tetrahydrofuran acetogenins.
RSC Adv
; 9(69): 40368-40377, 2019 Dec 03.
Article
en En
| MEDLINE
| ID: mdl-35542676
ABSTRACT
Annonaceous acetogenins have a wide range of potential biological activities. The development of simple and diversity-oriented approaches to their synthesis is therefore important. We have achieved the first total synthesis of squafosacin F and assigned its absolute configuration. The key steps were an acid-mediated tandem intramolecular double cyclization to build the hydroxy-flanked mono-tetrahydrofuran core and decoration with the desired functionalities of the target natural product via highly stereoselective reactions.
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Colección:
01-internacional
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MEDLINE
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En
Revista:
RSC Adv
Año:
2019
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Article