Pathways from Immune Profiling to Therapies for Rare Diseases.

ABSTRACT

Single-cell transcriptomic profiling has enhanced the description of several diseases. Beyond improving our understanding of the pathophysiology of these diseases, these approaches can lead to clues about therapeutic approaches. In a recent issue of Cell, Wang et al. describe immune perturbations in livers of biliary atresia patients that implicate specific autoimmune pathways of disease.1.