Cytoprotective agents in experimental small bowel volvulus.
J Pediatr Surg
; 22(3): 260-3, 1987 Mar.
Article
en En
| MEDLINE
| ID: mdl-3559871
ABSTRACT
An accepted experimental model for midgut volvulus was used to produce small bowel strangulation obstruction of 48 hours duration in Sprague-Dawley rats. A 93% perioperative mortality rate resulted after release of the volvulus. Treatment with three cytoprotective agents at the time of volvulus release resulted in the following mortality rates superoxide dismutase, 89%; ibuprofen, 50%; prostaglandin E1 (PGE1, 11%. The predominant cause of death in all treatment groups was bowel infarction, with a smaller number succumbing to either sepsis or circulatory collapse. Concomitant administration of ephedrine or indomethacin to suppress prostaglandin E1's splanchnic vasodilatory activity did not cause any increase in mortality. A trial of aspirin, to simulate PGE's antiplatelet actions, showed no reduction in mortality when compared with detorsion alone. Prostaglandin E1 and, to a lesser extent, ibuprofen, appear to have cytoprotective effects during reperfusion of bowel compromised by volvulus, independent of their influence on the mesenteric vasculature and thrombogenesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Obstrucción Intestinal
/
Intestino Delgado
Límite:
Animals
Idioma:
En
Revista:
J Pediatr Surg
Año:
1987
Tipo del documento:
Article