Targeting Necroptosis as a Promising Therapy for Alzheimer's Disease.
ACS Chem Neurosci
; 13(12): 1697-1713, 2022 06 15.
Article
en En
| MEDLINE
| ID: mdl-35607807
ABSTRACT
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder featured by memory loss and cognitive default. However, there has been no effective therapeutic approach to prevent the development of AD and the available therapies are only to alleviate some symptoms with limited efficacy and severe side effects. Necroptosis is a new kind of cell death, being regarded as a genetically programmed and regulated pattern of necrosis. Increasing evidence reveals that necroptosis is tightly related to the occurrence and development of AD. This review aims to summarize the potential role of necroptosis in AD progression and the therapeutic capacity of targeting necroptosis for AD patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Necroptosis
Límite:
Humans
Idioma:
En
Revista:
ACS Chem Neurosci
Año:
2022
Tipo del documento:
Article
País de afiliación:
China