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Efficacy and safety of Elian Granules in treating chronic atrophic gastritis: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial.
Gu, Zhijian; Jia, Qingling; Cong, Jun; Cen, Rong; Chen, Yongqi; Wu, Chenheng; Gong, Biao; Tang, Xudong; Ling, Jianghong.
Afiliación
  • Gu Z; Department of Gastroenterology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 185 Pu'an Road, Huangpu District, Shanghai, 200021, China.
  • Jia Q; Department of Gastroenterology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 185 Pu'an Road, Huangpu District, Shanghai, 200021, China.
  • Cong J; Department of Gastroenterology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 185 Pu'an Road, Huangpu District, Shanghai, 200021, China.
  • Cen R; Endoscopy Center, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Chen Y; Department of Pathology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Wu C; Department of Gastroenterology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 185 Pu'an Road, Huangpu District, Shanghai, 200021, China.
  • Gong B; Department of Gastroenterology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 185 Pu'an Road, Huangpu District, Shanghai, 200021, China. gbercp@163.com.
  • Tang X; Institute of Spleen and Stomach Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. txdly@sina.com.
  • Ling J; Department of Gastroenterology, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 185 Pu'an Road, Huangpu District, Shanghai, 200021, China. ljh18817424778@163.com.
Trials ; 23(1): 437, 2022 May 24.
Article en En | MEDLINE | ID: mdl-35610625
BACKGROUND: Multifocal atrophic gastritis and intestinal metaplasia are considered to be important links in the gastric precancerous cascade. However, there are no specific drugs for these conditions. Although many studies have shown that traditional Chinese medicine is effective with no serious side effects, these studies have not been scientifically rigorous trials. Our aim is to design a high-quality trial for a Chinese patent medicine, Elian Granules, to investigate its efficacy and safety in treating patients with chronic atrophic gastritis with or without intestinal metaplasia. METHODS: This is a phase II, randomized, double-blind, placebo-controlled, multicenter clinical trial. A total of 240 participants will be assigned to a treatment or placebo control group in a 1:1 ratio. The experimental drug or placebo will be taken with boiling water, two small bags (24.2 g) each time, twice a day, half an hour after a meal, for 24 weeks. The primary outcome is the observation of histological changes in the gastric mucosa of patients with atrophic gastritis with or without intestinal metaplasia after 6 months based on the OLGA/OLGIM staging systems. The secondary outcomes include the assessment of dyspepsia and quality of life based on the dyspepsia symptom score and the quality-of-life scale. DISCUSSION: This study is designed to evaluate the efficacy and safety of Elian Granules in a randomized, double-blind, placebo-controlled, multicenter manner. This trial may not only provide evidence for a phase III clinical trial, but also an alternative option for the treatment of chronic atrophic gastritis (CAG). TRIAL REGISTRATION: Registry Platform For Evidence-Based Traditional Chinese Medicine ChiMCTR2000003929 . Registered on 13 September 2020.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Dispepsia / Gastritis Atrófica Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Dispepsia / Gastritis Atrófica Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido