Static and temporal dynamic changes of intrinsic brain activity in pediatric and adults OCD.
J Affect Disord
; 311: 416-424, 2022 08 15.
Article
en En
| MEDLINE
| ID: mdl-35618169
ABSTRACT
Epidemiological and clinical age differences in obsessive-compulsive disorder (OCD) have been reported in clinical symptoms and morphometry changes; however, age differences in amplitude of low-frequency fluctuation and the relationship between ALFF imaging and clinical symptoms has not been thoroughly studied in OCD. Age may be an important feature associated with distinct subtypes of OCD. To examine the effect of age on OCD, the current study enrolled 92 OCD patients (32 pediatrics and 60 adults) and matched HCs (33 pediatrics and 84 adults), undergoing resting-state functional magnetic resonance imaging. The spontaneous brain activity was measured by static and dynamic amplitude of low-frequency fluctuation (ALFF) followed by two-way ANOVA. In pediatric OCD patients versus adult patients, we observed a significantly higher ALFF in the default mode network (DMN), including posterior cingulate, precuneus and superior frontal gyrus, and extending to cuneus, lingual gyrus. Additionally, the increased ALFF and dynamic ALFF in the precentral gyrus were found in pediatric patients. In OCD patients compared with controls, we found a significantly increased ALFF in hippocampal gyrus, cerebellum network (CN), and the dALFF in middle and inferior occipital gyrus, bilateral paracentral lobule and sensorimotor network. The findings emphasized the different patterns of static and dynamic intrinsic brain activity alterations associated with pediatric and adult OCD patients. These results provide unique insights into constructing evidenced-based distinct OCD subtypes based on brain activity and point the need of specified management for pediatric and adult OCD patients in clinical setting.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pediatría
/
Trastorno Obsesivo Compulsivo
Límite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
J Affect Disord
Año:
2022
Tipo del documento:
Article