Photodynamic Therapy for Treatment of Disease in Children-A Review of the Literature.

ABSTRACT

Photodynamic therapy is a mode of treatment whereby local irradiation of an administered photosensitizer with light of a specific wavelength generates cytotoxic reactive oxygen species. Despite the upward trend in the popularity of this method in adults, it is not yet commonly used in the treatment of children. Due to certain limitations, underdeveloped treatment regimens and potential side effects, the use of photodynamic therapy in the pediatric population is still in the initial phases of evaluation in clinical trials. METHOD: This study is a review of articles in English from the databases PubMed and Web of Science retrieved by applying the search term "photodynamic therapy in children" from 2000-2020. RESULTS: Based on the literature review, we analyze selected pediatric clinical cases in which photodynamic therapy was used for treatment in children. Examples of photodynamic therapy for treatment of dermatological diseases, diseases of the mucosa of the upper respiratory tract, halitosis, eye diseases and brain tumors are described. The paper describes the effectiveness of anti-cancer photodynamic therapy, including its use in antibacterial therapy. CONCLUSIONS: The results of the analysis suggest the potential of photodynamic therapy for the treatment of various diseases in children.