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αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading.
Willey, Jeffrey S; Aunon-Chancellor, Serena; Miles, Lauren A; Moore, Joseph E; Mao, Xiao W; Wallace, Robert W; Foy, Matthew C.
Afiliación
  • Willey JS; Department of Radiation Oncology, Wake Forest School of Medicine, Section of Radiation Biology, Winston-Salem, NC, USA. jwilley@wakehealth.edu.
  • Aunon-Chancellor S; Department of Internal Medicine, Louisiana State University Medical Center, Baton Rouge, LA, USA.
  • Miles LA; Department of Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Moore JE; Department of Radiation Oncology, Wake Forest School of Medicine, Section of Radiation Biology, Winston-Salem, NC, USA.
  • Mao XW; Department of Basic Sciences, Loma Linda University, Loma Linda, CA, USA.
  • Wallace RW; Department of Internal Medicine, Louisiana State University Medical Center, Baton Rouge, LA, USA.
  • Foy MC; Department of Internal Medicine, Louisiana State University Medical Center, Division of Nephrology, Baton Rouge, LA, USA.
NPJ Microgravity ; 8(1): 18, 2022 Jun 02.
Article en En | MEDLINE | ID: mdl-35654945
ABSTRACT
Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho plasma αKlotho recovered with exercise after HU.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Microgravity Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Microgravity Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos