Amelioration of TPA-induced skin inflammation by the leaf extract of Vernonia amygdalina involves ERK/STAT3 (Ser727) signaling inhibition.

Wu, Jia-Ying; Xie, Jian-Hua; Chen, Ying-Jie; Fu, Xiu-Qiong; Wang, Rui-Jun; Deng, Yu-Yi; Wang, Shuo; Yu, Hai-Xia; Liang, Chun; Yu, Zhi-Ling

Wu, Jia-Ying; Xie, Jian-Hua; Chen, Ying-Jie; Fu, Xiu-Qiong; Wang, Rui-Jun; Deng, Yu-Yi; Wang, Shuo; Yu, Hai-Xia; Liang, Chun; Yu, Zhi-Ling.

Afiliación

Wu JY; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Xie JH; Department of Food and Biological Engineering, Zhangzhou Institute of Technology, China.
Chen YJ; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Fu XQ; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Wang RJ; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Deng YY; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Wang S; Dalian Fusheng Natural Medicine Research Institute, China.
Yu HX; Jilin Yatai Traditional Chinese Medicine Innovation Research Institute, China.
Liang C; Division of Life Science and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, China.
Yu ZL; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. Electronic address: zlyu@hkbu.e

Phytomedicine ; 102: 154194, 2022 Jul 20.

Article en En | MEDLINE | ID: mdl-35660348

Asunto(s)

Factor de Transcripción STAT3; Vernonia; Animales; Antiinflamatorios/farmacología; Antiinflamatorios/uso terapéutico; Edema/tratamiento farmacológico; Etanol; Quinasas MAP Reguladas por Señal Extracelular/metabolismo; Inflamación/inducido químicamente; Inflamación/tratamiento farmacológico; Interleucina-6/metabolismo; Lipopolisacáridos/farmacología; Ratones; FN-kappa B/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintasa de Tipo II/metabolismo; Extractos Vegetales/uso terapéutico; ARN Mensajero; Ratas; Factor de Transcripción STAT3/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Acute inflammation; COX-2, cyclooxygenase-2; ERK; ERK, extracellular signal-regulated kinase; IL, interleukin; MAPK, mitogen-activated protein kinase; NO, nitric oxide; STAT3; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor-α; TPA; VA, Vernonia amygdalina Del.; VAE, the 95% ethanol extract of VA leaves; Vernonia amygdalina; iNOS, inducible nitric oxide synthase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vernonia / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania

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