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Enhancing Prolonged Exposure therapy for PTSD using physiological biomarker-driven technology.
Back, Sudie E; Acierno, Ron; Saraiya, Tanya C; Harley, Bill; Wangelin, Bethany; Jarnecke, Amber M; McTeague, Lisa M; Brown, Delisa G; Ana, Elizabeth Santa; Rothbaum, Alex O; Adams, Robert J.
Afiliación
  • Back SE; Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Acierno R; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
  • Saraiya TC; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
  • Harley B; Faillace Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Wangelin B; Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Jarnecke AM; Zeriscope, Inc., Charleston, SC, USA.
  • McTeague LM; Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Brown DG; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
  • Ana ES; Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Rothbaum AO; Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Adams RJ; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
Contemp Clin Trials Commun ; 28: 100940, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35664505
Prolonged Exposure (PE) therapy is one of the most efficacious, evidence-based treatments for posttraumatic stress disorder (PTSD). A key component of PE involves in vivo exposures (IVEs) during which patients approach situations or activities in "real life" that are safe but avoided because they elicit a fear response. Despite their critical role in treatment, little research has focused on IVEs. This gap in knowledge is primarily due to the fact that IVEs are typically conducted by patients in between therapy sessions, leaving clinicians reliant upon patient self-report. This approach has numerous shortcomings, which the current study addresses by leveraging technology to develop an innovative device that allows for physiological, biomarker-driven, therapist-guided IVEs. The new system enables clinicians to virtually accompany patients during IVEs and provides real-time physiological (heart rate, skin conductance) and self-report (subjective units of distress) data that clinicians can use to modify the exposure and optimize therapeutic value. This Small Business Innovation Research (SBIR) Phase I project aims to: (1) integrate physiological sensors and live audio/visual streaming into a system for clinicians to guide patients during IVEs; (2) determine feasibility and acceptability of the system; and (3) conduct a pilot randomized clinical trial among veterans with PTSD (N = 40) to evaluate the preliminary efficacy of the system in reducing PTSD symptoms during PE. This paper describes the rationale, design, and methodology of the Phase I project. The findings from this study have the potential to innovate clinical practice, advance the science of exposure therapy, and improve clinical outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Contemp Clin Trials Commun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Contemp Clin Trials Commun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos