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Whole transcriptome analysis of long noncoding RNA in beryllium sulfate-treated 16HBE cells.
Chen, Shaoxiong; Sun, Zhanbing; Deng, Weihua; Li, Guilan; Liu, Xiuli; Zhang, Zhaohui.
Afiliación
  • Chen S; Department of Preventive Medicine, School of public health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
  • Sun Z; Department of Preventive Medicine, School of public health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
  • Deng W; Department of Preventive Medicine, School of public health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
  • Li G; Department of Preventive Medicine, School of public health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
  • Liu X; Department of Preventive Medicine, School of public health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
  • Zhang Z; Department of Preventive Medicine, School of public health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China. Electronic address: nhzzh@usc.edu.cn.
Toxicol Appl Pharmacol ; 449: 116097, 2022 08 15.
Article en En | MEDLINE | ID: mdl-35679967
Beryllium and its compounds can cause pulmonary interstitial fibrosis through mechanisms that are not yet clear. Long non-coding RNA (lncRNA) is implicated in various diseases. The molecular toxicity of beryllium sulfate (BeSO4) was investigated through the RNA-seq analysis of the lncRNA and mRNA whole-transcriptome of BeSO4-treated 16HBE cells. A total of 1014 lncRNAs (535 upregulated and 479 downregulated) and 4035 mRNAs (2224 upregulated and 1811 downregulated) were found to be significantly dysregulated (|logFC| ≥> 2.0, p < 0.05) in the BeSO4-treated groups when compared with the control group. Five differentially expressed lncRNAs and mRNAs were verified by qRT-PCR. KEGG analysis showed that lncRNA regulates the ECM receiver interaction and PI3K/AKT signaling pathways, etc. In addition, H19:17, lnc-C5orf13-1:1, lnc-CRYAA-17:1, lnc-VSTM5-1:11, and lnc-THSD7A-7:1 may regulate BeSO4-induced 16HBE cytotoxicity through ceRNA mechanism. The results of this study will provide some theoretical support for the study of the toxic mechanism of beryllium and its compounds.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Largo no Codificante Idioma: En Revista: Toxicol Appl Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Largo no Codificante Idioma: En Revista: Toxicol Appl Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos