Mediating Effect of Physical Activity in the Association between Low 25-Hydroxyvitamin D and Frailty Trajectories: The English Longitudinal Study of Ageing.
Nutrients
; 14(11)2022 May 30.
Article
en En
| MEDLINE
| ID: mdl-35684092
ABSTRACT
BACKGROUND:
Frailty is associated with adverse health outcomes, and vitamin D (VD) deficiency may be a risk factor. We aimed to identify frailty trajectories and examine the mediating effect of physical activity (PA) on the association between VD deficiency and frailty trajectories.METHODS:
We included 2997 participants aged 60 to 85 years from ELSA. VD was measured using serum 25-hydroxyvitamin D [25(OH)D] (sufficient >50; insufficient 30−50; deficient <30 nmol/L). Frailty was assessed by a 60-item frailty index, and PA was measured on the basis of total energy expenditure. Frailty trajectories were identified using group-based trajectory modeling, and the mediation effect of PA was tested using causal mediation analysis.RESULTS:
Three distinct frailty trajectories emerged "Non-frail" (66.48%), "Pre-frail to frail" (25.67%) and "Frail to severely frail" (7.85%). VD deficiency was associated with the "Pre-frail to frail" (OR = 1.51, 95% CI 1.14, 1.98) and "Frail to severely frail" trajectories (OR = 2.29, 95% CI 1.45, 3.62). PA only mediated 48.4% (95% CI 17.1%−270.8%) of the association between VD deficiency and the "Pre-frail to frail" trajectory.CONCLUSIONS:
Vitamin D deficiency is associated with the onset and worsening of frailty in older adults, and reduced PA may mediate its impact on the transition from pre-frailty to frailty.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina D
/
Fragilidad
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Humans
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Middle aged
Idioma:
En
Revista:
Nutrients
Año:
2022
Tipo del documento:
Article
País de afiliación:
China