[The antiviral targeting potential of viroporins].
Ugeskr Laeger
; 184(24)2022 06 13.
Article
en Da
| MEDLINE
| ID: mdl-35703076
ABSTRACT
Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine and rimantadine. In this review, we seek to utilize the inhibition by amantadine of the viroporin Protein E in SARS-CoV-2 in an attempt to treat COVID-19 in its early stages. We are executing a double-blinded placebo-controlled trial based on promising in vivo and in vitro work as a stepping-stone for establishing a therapeutic antiviral regime blocking of viroporins.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Tratamiento Farmacológico de COVID-19
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
2022
Tipo del documento:
Article