Protective effects and possible mechanism of 6-gingerol against arsenic trioxide-induced nephrotoxicity based on network pharmacological analysis and experimental validation.

Han, Xue; Yang, Yakun; Qi, Jiaying; Zhang, Muqing; Xue, Yucong; Chu, Xi; Jia, Qingzhong; Sun, Shijiang; Guan, Shengjiang

Han, Xue; Yang, Yakun; Qi, Jiaying; Zhang, Muqing; Xue, Yucong; Chu, Xi; Jia, Qingzhong; Sun, Shijiang; Guan, Shengjiang.

Afiliación

Han X; School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Yang Y; School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Qi J; School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Zhang M; College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Xue Y; College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Chu X; The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jia Q; School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address: qizhjia@hebmu.edu.cn.
Sun S; Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. Electronic address: sunshijiang6909@163.com.
Guan S; Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; School of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. Electronic address: guanshengjiang123@126.com.

Int Immunopharmacol ; 110: 108926, 2022 Sep.

Article en En | MEDLINE | ID: mdl-35728306

Asunto(s)

Arsenicales; Animales; Antiinflamatorios; Antioxidantes; Trióxido de Arsénico; Arsenicales/farmacología; Catecoles; Alcoholes Grasos; Ratones; Óxidos

Palabras clave

6-gingerol; Apoptosis; Arsenic trioxide; MAPKs signaling pathway; Nephrotoxicity; Network pharmacology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsenicales Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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