Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
J Nat Prod
; 85(6): 1514-1521, 2022 06 24.
Article
en En
| MEDLINE
| ID: mdl-35748039
ABSTRACT
Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by microorganisms. Here we show that the two natural products triculamin and alboverticillin, originally isolated in 1967 and 1958, respectively, with potent and specific activity against mycobacteria are in fact the same lasso peptide. We solved the structure using 2D NMR spectroscopy and expanded on the previously reported bioactivity. Through genome sequencing, we identify the responsible biosynthetic gene clusters, which curiously revealed that, unlike any known lasso peptides, their precursor peptides appear to have a follower instead of a leader peptide.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Procesamiento Proteico-Postraduccional
Idioma:
En
Revista:
J Nat Prod
Año:
2022
Tipo del documento:
Article
País de afiliación:
Dinamarca