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Sustained drug delivery strategies for treatment of common substance use disorders: Promises and challenges.
Tijani, Akeemat O; Garg, Jivesh; Frempong, Dorcas; Verana, Gabrielle; Kaur, Jagroop; Joga, Ramesh; Sabanis, Chetan D; Kumar, Sandeep; Kumar, Neeraj; Puri, Ashana.
Afiliación
  • Tijani AO; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address: tijaniao@etsu.edu.
  • Garg J; University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
  • Frempong D; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address: frempong@mail.etsu.edu.
  • Verana G; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address: verana@mail.etsu.edu.
  • Kaur J; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address: kaurj1@mail.etsu.edu.
  • Joga R; Department of Regulatory Affairs, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Telangana, India. Electronic address: ramesh.joga@niperhyd.ac.in.
  • Sabanis CD; Department of Regulatory Affairs, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Telangana, India. Electronic address: sabnis.chetan@niperhyd.ac.in.
  • Kumar S; Department of Regulatory Affairs, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Telangana, India. Electronic address: sandeepkumar.ra@niperhyd.ac.in.
  • Kumar N; Department of Regulatory Affairs, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Telangana, India. Electronic address: neeraj.k16@niperhyd.ac.in.
  • Puri A; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address: puria1@etsu.edu.
J Control Release ; 348: 970-1003, 2022 08.
Article en En | MEDLINE | ID: mdl-35752256
Substance use disorders (SUDs) are a leading cause of death and other ill health effects in the United States and other countries in the world. Several approaches ranging from detoxification, behavioral therapy, and the use of antagonists or drugs with counter effects are currently being applied for its management. Amongst these, drug therapy is the mainstay for some drug abuse incidences, as is in place specifically for opioid abuse or alcohol dependence. The severity of the havocs observed with the SUDs has triggered constant interest in the discovery and development of novel medications as well as suitable or most appropriate methods for the delivery of these agents. The chronic need of such drugs in users warrants the need for their prolonged or sustained systemic availability. Further, the need to improve patient tolerance to medication, limit invasive drug use and overall treatment outcome are pertinent considerations for embracing sustained release designs for medications used in managing SUDs. This review aims to provide an overview on up-to-date advances made with regards to sustained delivery systems for the drugs for treatment of different types of SUDs such as opioid, alcohol, tobacco, cocaine, and cannabis use disorders. The clinical relevance, promises and the limitations of deployed sustained release approaches along with future opportunities are discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcoholismo / Trastornos Relacionados con Opioides Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcoholismo / Trastornos Relacionados con Opioides Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos