ANOVA, One-way analysis of variance; ASC, Apoptosis-associated speck-like protein containing a CARD; CBF, cerebral blood flow; CIRI, cerebral ischemia/reperfusion injury; CN, Calcineurin; Calcium overload; Cerebral ischemia-reperfusion injury (CIRI); DHE, Dihydroethidium; FBS, fetal bovine serum; Ginsenoside Rg1; I/R, ischemia reperfusion; IL-1ß, Interleukin-1ß; IPP, Image-Pro Plus; MAP2, microtubule-associated protein 2; NADPH oxidase 2; NFAT1, nuclear factor of activated T-cells 1; NLRP1 inflammasome; NLRP1, Nucleotide-binding oligomerization domain like receptor protein 1; NMDA, N-methyl-d-aspartate; NOD, nucleotide-binding oligomerization domain; NOX, Nicotinamide adenine dinucleotide phosphate oxidase; OFT, Open field test; OGD/R, oxygen glucose deprivation/reperfusion; PCT, Pole-climbing test; PIP2, phosphatidyl-inositol bisphosphate; PLC, phospholipase C; PSD95, postsynaptic density protein 95; ROS, reactive oxygen species; Rg1, Ginsenoside Rg1; SCII, Spinal cord ischemia-reperfusion injury; TBST, Tris buffered saline Tween; caspase-1, Cysteinyl aspartate-specific protease-1