Enantioselective Synthesis of Î´-Carbolinones via N-Heterocyclic Carbene Catalysis.

Zhang, Simiao; Lin, Chen; Liu, Chaolei; Du, Ding

Zhang, Simiao; Lin, Chen; Liu, Chaolei; Du, Ding.

Afiliación

Zhang S; State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.
Lin C; State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.
Liu C; State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.
Du D; State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.

J Org Chem ; 87(15): 10441-10448, 2022 08 05.

Article en En | MEDLINE | ID: mdl-35819024

ABSTRACT

ABSTRACT

An enantioselective synthesis of Î´-carbolinones was accomplished through N-heterocyclic carbene-catalyzed formal [3+3] annulation of 3-aminoindoles with 2-bromoenals. This protocol offers a rapid and efficient synthetic approach for accessing a wide range of enantioenriched structurally interesting Î´-carbolinones under mild reaction conditions.

Asunto(s)

Compuestos Heterocíclicos; Catálisis; Metano/análogos & derivados; Estereoisomerismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Heterocíclicos Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article

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