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Chimonanthus nitens Oliv. Leaf Granule Ameliorates DSS-Induced Acute Colitis Through Treg Cell Improvement, Oxidative Stress Reduction, and Gut Microflora Modulation.
Huang, Jia-Qi; Wei, Si-Yi; Cheng, Nian; Zhong, You-Bao; Yu, Fei-Hao; Li, Ming-Da; Liu, Duan-Yong; Li, Shan-Shan; Zhao, Hai-Mei.
Afiliación
  • Huang JQ; Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Wei SY; Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Cheng N; Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Zhong YB; Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Yu FH; Laboratory Animal Research Center for Science and Technology, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Li MD; Key Laboratory of Animal Model of Traditional Chinese Medicine (TCM) Syndromes of Depression, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Liu DY; Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
  • Li SS; College of Traditional Chinese Medicine, Nanchang Medical College (TCM), Nanchang, China.
  • Zhao HM; Formula-Pattern Research Center of Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, China.
Front Cell Infect Microbiol ; 12: 907813, 2022.
Article en En | MEDLINE | ID: mdl-35832382
The rising incidence of ulcerative colitis has become a new challenge for public health. Chimonanthus nitens Oliv. leaf granule (COG) is a natural medicine used for the treatment of respiratory diseases, which has excellent anti-inflammatory and antioxidant effects. However, the therapeutic effect of COG in ulcerative colitis (UC) has not been reported. Here, the experimental colitis was treated with dextran sodium sulfate (DSS) and COG. After treatment with high (30 g/kg), medium (15 g/kg), and low (7.5 g/kg) doses of COG for 11 consecutive days, the body weight, disease activity index (DAI) score, colon length, colon weight index, and the pathological score of mice were effectively improved. COG significantly reduced the levels of inflammatory cytokines in UC mice in vitro and in vivo and restored the secretion levels of IL-6 and IL-10 in the colon. Meanwhile, compared to mice with colitis, COG-treated mice showed lower levels of MDA, MPO, NO, and eNOS and higher levels of GSH-Px and MAO, which indicated that oxidative stress damage in colitic mice was alleviated by COG. Moreover, less Th17 and more Tregs were observed in the COG-treated groups. In addition, COG improved the diversity and relative abundance of gut microflora in the colon of colitic mice, and Lachnospiraceae_NK4A136_group and Lachnospiraceae_UCG-006 were obviously regulated at the genus level. In summary, COG has a protective effect on DSS-induced experimental colitis, mainly through inhibition of immune-inflammatory responses and oxidative stress and regulation of mTreg cell responses and intestinal flora composition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Front Cell Infect Microbiol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Front Cell Infect Microbiol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza