The impact of varying dextran oxidation levels on the inhibitory activity of a bacteriocin loaded injectable hydrogel.
Drug Deliv Transl Res
; 13(1): 308-319, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-35851672
ABSTRACT
In the design of injectable antimicrobial dextran-alginate hydrogels, the impact of dextran oxidation and its subsequent changes in molecular weight and the incorporation of glycol chitosan on (i) gel mechanical strength and (ii) the inhibitory profile of an encapsulated bacteriocin, nisin A, are explored. As the degree of oxidation increases, the weight average molecular mass of the dextran decreases, resulting in a reduction in elastic modulus of the gels made. Upon encapsulation of the bacteriocin nisin into the gels, varying the dextran mass/oxidation level allowed the antimicrobial activity against S. aureus to be controlled. Gels made with a higher molecular weight (less oxidised) dextran show a higher initial degree of inhibition while those made with a lower molecular weight (more oxidised) dextran exhibit a more sustained inhibition. Incorporating glycol chitosan into gels composed of dextran with higher masses significantly increased their storage modulus and the gels' initial degree of inhibition.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacteriocinas
/
Antiinfecciosos
Idioma:
En
Revista:
Drug Deliv Transl Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
Irlanda