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Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Orr, Christian M; Fisher, Hayden; Yu, Xiaojie; Chan, Claude H-T; Gao, Yunyun; Duriez, Patrick J; Booth, Steven G; Elliott, Isabel; Inzhelevskaya, Tatyana; Mockridge, Ian; Penfold, Christine A; Wagner, Armin; Glennie, Martin J; White, Ann L; Essex, Jonathan W; Pearson, Arwen R; Cragg, Mark S; Tews, Ivo.
Afiliación
  • Orr CM; University of Southampton, Biological Sciences, Southampton SO17 1BJ, UK.
  • Fisher H; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Yu X; Hamburg Centre for Ultrafast Imaging CFEL, Hamburg 22761, Germany.
  • Chan CH; Diamond Light Source, Didcot OX11 0FA, UK.
  • Gao Y; University of Southampton, Biological Sciences, Southampton SO17 1BJ, UK.
  • Duriez PJ; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Booth SG; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Elliott I; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Inzhelevskaya T; Hamburg Centre for Ultrafast Imaging CFEL, Hamburg 22761, Germany.
  • Mockridge I; Institute for Nanostructure and Solid State Physics, Hamburg 22761, Germany.
  • Penfold CA; Max Planck Institute for the Structure and Dynamics of Matter, Hamburg 22761, Germany.
  • Wagner A; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Glennie MJ; University of Southampton, CRUK Protein Core Facility, Southampton, SO16 6YD, UK.
  • White AL; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Essex JW; University of Southampton, Biological Sciences, Southampton SO17 1BJ, UK.
  • Pearson AR; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
  • Cragg MS; University of Southampton, School of Chemistry, Southampton SO17 1BJ, UK.
  • Tews I; University of Southampton, Centre for Cancer Immunology, Southampton SO16 6YD, UK.
Sci Immunol ; 7(73): eabm3723, 2022 07 15.
Article en En | MEDLINE | ID: mdl-35857577
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Disulfuros Límite: Humans Idioma: En Revista: Sci Immunol Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Disulfuros Límite: Humans Idioma: En Revista: Sci Immunol Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos