Effect of the combinatorial iron-chelation and oxidative stress on the growth of Aspergillus species.
Res Microbiol
; 173(8): 103969, 2022.
Article
en En
| MEDLINE
| ID: mdl-35863560
ABSTRACT
The growth of 14 Aspergillus strains belonging to nine species was studied under combinatorial deferriprone - H2O2 (iron-chelation - oxidative) stress. When deferriprone pretreated mycelia were subjected to even a weak oxidative stress, the growth inhibitory effect of iron-chelation stress was enhanced in 10 out of 14 strains. In contrast, oxidative stress pretreatment of conidia increased their deferriprone tolerance in 10 strains. Applying iron-chelators as antifungal agent or adjuvant can enhance the efficiency of the combinatorial iron withdrawal - oxidative stress strategy of our immune system and may reduce the survival of conidia escaped from the oxidative attack of pulmonary macrophages.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspergillus fumigatus
/
Peróxido de Hidrógeno
Idioma:
En
Revista:
Res Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2022
Tipo del documento:
Article