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Associations Between Vascular Risk Factors and Perivascular Spaces in Adults with Intact Cognition, Mild Cognitive Impairment, and Dementia.
Rundek, Tatjana; Del Brutto, Victor J; Goryawala, Mohammed; Dong, Chuanhui; Agudelo, Christian; Saporta, Anita Seixas; Merritt, Stacy; Camargo, Christian; Ariko, Taylor; Loewenstein, David A; Duara, Ranjan; Haq, Ihtsham.
Afiliación
  • Rundek T; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Del Brutto VJ; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Goryawala M; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Dong C; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Agudelo C; Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Saporta AS; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Merritt S; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Camargo C; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Ariko T; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Loewenstein DA; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Duara R; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Haq I; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
J Alzheimers Dis ; 89(2): 437-448, 2022.
Article en En | MEDLINE | ID: mdl-35871327
BACKGROUND: Perivascular spaces (PVS) are fluid-filled compartments surrounding small intracerebral vessels that transport fluid and clear waste. OBJECTIVE: We examined associations between PVS count, vascular and neurodegenerative risk factors, and cognitive status among the predominantly Hispanic participants of the FL-VIP Study of Alzheimer's Disease Risk. METHODS: Using brain MRI (n = 228), we counted PVS in single axial image through the basal ganglia (BG) and centrum semiovale (CSO). PVS per region were scored as 0 (none), 1 (<10), 2 (11-20), 3 (21-40), and 4 (>40). Generalized linear models examined PVS associations with vascular risk factors and a composite vascular comorbidity risk (VASCom) score. RESULTS: Our sample (mean age 72±8 years, 61% women, 60% Hispanic, mean education 15±4 years, 33% APOE4 carriers) was 59% hypertensive, 21% diabetic, 66% hypercholesteremic, and 30% obese. Mean VASCom score was 2.3±1.6. PVS scores ranged from 0-4 in the BG (mean 1.3±0.7) and CSO (mean 1.2±0.9), and 0-7 combined (mean 2.5±1.4). In multivariable regression models, BG PVS was associated with age (ß= 0.03/year, p < 0.0001), Hispanic ethnicity (ß= 0.29, p = 0.01), education (ß= 0.04/year, p = 0.04), and coronary bypass surgery (ß= 0.93, p = 0.02). CSO PVS only associated with age (ß= 0.03/year, p < 0.01). APOE4 and amyloid-ß were not associated with PVS. CONCLUSION: BG PVS may be a marker of subclinical cerebrovascular disease. Further research is needed to validate associations and identify mechanisms linking BG PVS and cerebrovascular disease markers. PVS may be a marker of neurodegeneration despite our negative preliminary findings and more research is warranted. The association between BG PVS and Hispanic ethnicity also requires further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos