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Clonal B-cell proliferations developing in the background of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: A case series.
Ates Ozdemir, Deniz; Akdogan, Neslihan; Okay, Müfide; Uner, Aysegül; Saglam, Arzu.
Afiliación
  • Ates Ozdemir D; Department of Pathology, Hacettepe University, Ankara, Turkey.
  • Akdogan N; Department of Dermatology, Hacettepe University, Ankara, Turkey.
  • Okay M; Department of Hematology, Ministry of Health, Eskisehir City Hospital, Eskisehir, Turkey.
  • Uner A; Department of Pathology, Hacettepe University, Ankara, Turkey.
  • Saglam A; Department of Pathology, Hacettepe University, Ankara, Turkey.
J Cutan Pathol ; 49(11): 971-977, 2022 Nov.
Article en En | MEDLINE | ID: mdl-35871674
ABSTRACT
Clonal B-cell proliferations and B-cell lymphomas may co-occur in the background of follicular helper T-cell (TFH)-derived lymphomas, most associated with EBV, which has been a well-known fact for many years in the prototypical entity "TFH lymphoma, angioimmunoblastic-type." Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (CD4+ PCSM-LPD) is also a TFH-derived clonal proliferation. We searched the archives and identified four cases of CD4+ PCSM-LPD with accompanying clonal B-cell proliferation (one of which showed EBER positivity), and one longstanding case of CD4+ PCSM-LPD, in the background of which a B-cell lymphoma had developed. These five cases broaden experience on CD4+ PCSM-LPD with accompanying B-cell proliferations and also support routine evaluation of these cases with EBV in situ hybridization, to better determine whether or not there is an association with EBV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Linfoma de Células B / Trastornos Linfoproliferativos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cutan Pathol Año: 2022 Tipo del documento: Article País de afiliación: Turquía

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Linfoma de Células B / Trastornos Linfoproliferativos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cutan Pathol Año: 2022 Tipo del documento: Article País de afiliación: Turquía