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Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out.
Dechering, Koen J; Timmerman, Martijn; Rensen, Kim; Koolen, Karin M J; Honarnejad, Saman; Vos, Martijn W; Huijs, Tonnie; Henderson, Rob W M; Chenu, Elodie; Laleu, Benoît; Montefiore, Bailey C; Segall, Matthew D; Mills, James E J; Guantai, Eric M; Duffy, James; Duffey, Maëlle.
Afiliación
  • Dechering KJ; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
  • Timmerman M; Pivot Park Screening Centre, Oss, North Brabant, The Netherlands.
  • Rensen K; Pivot Park Screening Centre, Oss, North Brabant, The Netherlands.
  • Koolen KMJ; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
  • Honarnejad S; Pivot Park Screening Centre, Oss, North Brabant, The Netherlands.
  • Vos MW; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
  • Huijs T; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
  • Henderson RWM; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
  • Chenu E; Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.
  • Laleu B; Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.
  • Montefiore BC; Optibrium, F5-6 Blenheim House, Cambridge Innovation Park, Denny End Road, Cambridge CB25 9PB, United Kingdom.
  • Segall MD; Optibrium, F5-6 Blenheim House, Cambridge Innovation Park, Denny End Road, Cambridge CB25 9PB, United Kingdom.
  • Mills JEJ; Sandexis Medicinal Chemistry Ltd, Innovation House, Discovery Park, Sandwich, CT13 9FF, United Kingdom.
  • Guantai EM; Department of Pharmacy, Faculty of Health Sciences, University of Nairobi, 00202, Nairobi, Kenya.
  • Duffy J; Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.
  • Duffey M; Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland. Electronic address: duffeym@mmv.org.
SLAS Discov ; 27(6): 337-348, 2022 09.
Article en En | MEDLINE | ID: mdl-35872229
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria / Antimaláricos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: SLAS Discov Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria / Antimaláricos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: SLAS Discov Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos