Effect of Vaccination against Leptospira on Shelter Asymptomatic Dogs Following a Long-Term Study.
Animals (Basel)
; 12(14)2022 Jul 12.
Article
en En
| MEDLINE
| ID: mdl-35883334
ABSTRACT
(1) Background:
Vaccination of dogs against leptospirosis is of paramount importance, as they ideally must provide not only long-term protection, but also against the renal carrier state of leptospires. This study assessed the post-vaccine humoral response against Leptospira in naturally exposed dogs and effects on renal carrier status. (2)Methods:
A total of 118 dogs were studied for 365 days, separated into Group A (vaccinated, n = 94) and Group B (non-vaccinated, n = 24). Group A was subdivided into three groups A1 with 32 dogs immunized with the vaccine #1; A2 by 32 dogs with #2; and A3 30 dogs with #3. Serology (MAT and IgG-ELISA) and urinary PCR were conducted. (3)Results:
Seroreactivity increased at D15 post-vaccination and, regardless of vaccine brand, remained high up to D180, with antibody switch to IgG after D30. A total of 46.8% of animals from Group A were PCR-positive at least once, in contrast to 75% in Group B, regardless of vaccine brand (p < 0.05; OR 0.3). (4)Conclusions:
All commercial vaccines succeeded at eliciting a long-term IgG-based response and were partially effective at protecting against kidney infection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Animals (Basel)
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil