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The Role of PIM Kinases in Pediatric Solid Tumors.
Julson, Janet Rae; Marayati, Raoud; Beierle, Elizabeth Ann; Stafman, Laura Lee.
Afiliación
  • Julson JR; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
  • Marayati R; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
  • Beierle EA; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
  • Stafman LL; Division of Pediatric Surgery, Department of Surgery, Vanderbilt University, Nashville, TN 37240, USA.
Cancers (Basel) ; 14(15)2022 Jul 22.
Article en En | MEDLINE | ID: mdl-35892829
ABSTRACT
PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos