A new C19-diterpenoid alkaloid in Aconitum georgei Comber.
Nat Prod Res
; 38(1): 85-90, 2024.
Article
en En
| MEDLINE
| ID: mdl-35913407
ABSTRACT
Nine diterpenoid alkaloids were isolated from Aconitum georgei Comber belonging to the genus Aconitum in Ranunculaceae family. Their structures were determinated by using HR-ESI-MS and 1 D/2D NMR spectra as geordine (1), yunaconitine (2), chasmanine (3), crassicauline A (4), forestine (5), pseudaconine (6), 14-acetylalatisamine (7), austroconitine B (8), and talatisamine (9). Among them, compound 1 is a previously undescribed aconitine-type C19-diterpenoid alkaloid, and compounds 3, and 5-9 have not previously been isolated from this species. The results of in vitro experiments indicated that new compound 1 possesses mild anti-inflammatory activity, which inhibited the production of NO in LPS-activated RAW 264.7 cells with an inhibition ratio of 29.75% at 50 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Aconitum
/
Diterpenos
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Alcaloides
Idioma:
En
Revista:
Nat Prod Res
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido