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Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman, Richard; Renziehausen, Alexander; Shaye, Hamidreza; Kostagianni, Androniki D; Tsiailanis, Antonis D; Thorne, Thomas; Chatziathanasiadou, Maria V; Sivolapenko, Gregory B; El Mubarak, Mohamed Ahmed; Han, Gye Won; Zarzycka, Barbara; Katritch, Vsevolod; Lebon, Guillaume; Lo Nigro, Cristiana; Lattanzio, Laura; Morse, Sophie V; Choi, James J; O'Neill, Kevin; Kanaki, Zoi; Klinakis, Apostolos; Crook, Tim; Cherezov, Vadim; Tzakos, Andreas G; Syed, Nelofer.
Afiliación
  • Perryman R; John Fulcher Molecular Neuro-Oncology Laboratory, Department Brain Sciences, Imperial College, London, United Kingdom.
  • Renziehausen A; John Fulcher Molecular Neuro-Oncology Laboratory, Department Brain Sciences, Imperial College, London, United Kingdom.
  • Shaye H; Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
  • Kostagianni AD; Bridge Institute, University of Southern California, Los Angeles, CA 90089.
  • Tsiailanis AD; Department of Chemistry, University of Ioannina, Ioannina, Greece.
  • Thorne T; Department of Chemistry, University of Ioannina, Ioannina, Greece.
  • Chatziathanasiadou MV; Department of Computer Science, University of Surrey, Surrey, United Kingdom.
  • Sivolapenko GB; John Fulcher Molecular Neuro-Oncology Laboratory, Department Brain Sciences, Imperial College, London, United Kingdom.
  • El Mubarak MA; Department of Chemistry, University of Ioannina, Ioannina, Greece.
  • Han GW; Laboratory of Pharmacokinetics, Department of Pharmacy, University of Patras, Patras, Greece.
  • Zarzycka B; Laboratory of Pharmacokinetics, Department of Pharmacy, University of Patras, Patras, Greece.
  • Katritch V; Bridge Institute, University of Southern California, Los Angeles, CA 90089.
  • Lebon G; Bridge Institute, University of Southern California, Los Angeles, CA 90089.
  • Lo Nigro C; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
  • Lattanzio L; Bridge Institute, University of Southern California, Los Angeles, CA 90089.
  • Morse SV; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089.
  • Choi JJ; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, Montpellier, France.
  • O'Neill K; Department of Oncology, Ospedale San Croce e Carle, Cuneo, Italy.
  • Kanaki Z; Department of Oncology, Ospedale San Croce e Carle, Cuneo, Italy.
  • Klinakis A; John Fulcher Molecular Neuro-Oncology Laboratory, Department Brain Sciences, Imperial College, London, United Kingdom.
  • Crook T; Department of Bioengineering, Imperial College London, London, United Kingdom.
  • Cherezov V; Department of Bioengineering, Imperial College London, London, United Kingdom.
  • Tzakos AG; John Fulcher Molecular Neuro-Oncology Laboratory, Department Brain Sciences, Imperial College, London, United Kingdom.
  • Syed N; Department of Neurosurgery, Charing Cross Hospital, London, United Kingdom.
Proc Natl Acad Sci U S A ; 119(32): e2116289119, 2022 08 09.
Article en En | MEDLINE | ID: mdl-35917342
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Neoplasias Encefálicas / Glioblastoma / Receptor de Angiotensina Tipo 2 / Bloqueadores del Receptor Tipo 2 de Angiotensina II / Reposicionamiento de Medicamentos / Isoquinolinas Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Neoplasias Encefálicas / Glioblastoma / Receptor de Angiotensina Tipo 2 / Bloqueadores del Receptor Tipo 2 de Angiotensina II / Reposicionamiento de Medicamentos / Isoquinolinas Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido