Exploring enzyme inhibition profiles of novel halogenated chalcone derivatives on some metabolic enzymes: Synthesis, characterization and molecular modeling studies.

Anil, Derya Aktas; Polat, M Fatih; Saglamtas, Ruya; Tarikogullari, Ayse H; Alagoz, M Abdullah; Gulcin, Ilhami; Algul, Oztekin; Burmaoglu, Serdar

Anil, Derya Aktas; Polat, M Fatih; Saglamtas, Ruya; Tarikogullari, Ayse H; Alagoz, M Abdullah; Gulcin, Ilhami; Algul, Oztekin; Burmaoglu, Serdar.

Afiliación

Anil DA; Department of Chemistry and Chemical Process Technologies, Erzurum Vocational High School, Atatürk University, Erzurum 25240, Turkey.
Polat MF; Department of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yildirim University, Erzincan 24100, Turkey.
Saglamtas R; Central Research and Application Laboratory, Agri Ibrahim Cecen University, Agri 04100, Turkey.
Tarikogullari AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir 35100, Turkey.
Alagoz MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University, Malatya 44280, Turkey.
Gulcin I; Department of Chemistry, Faculty of Science, Atatürk University, Erzurum 25240, Turkey.
Algul O; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, Mersin 33169, Turkey; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: oztekinalgul@mersin.edu.tr.
Burmaoglu S; Department of Chemistry, Faculty of Science, Atatürk University, Erzurum 25240, Turkey. Electronic address: sboglu@atauni.edu.tr.

Comput Biol Chem ; 100: 107748, 2022 Oct.

Article en En | MEDLINE | ID: mdl-35917597

Asunto(s)

Chalcona; Chalconas; Acetilcolinesterasa/metabolismo; Butirilcolinesterasa/metabolismo; Inhibidores de Anhidrasa Carbónica/química; Inhibidores de la Colinesterasa/química; Humanos; Simulación del Acoplamiento Molecular; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

Acetylcholinesterase; Butyrylcholinesterase; Carbonic anhydrase; Chalcone; Enzyme inhibition; Molecular docking

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chalcona / Chalconas Límite: Humans Idioma: En Revista: Comput Biol Chem Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido

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